"Functional Nanoscale Imaging of Protein Surfaces"

Paul D. Cristea, Professor, Biomedical Engineering Center, University "Politehnica" of Bucharest, Romania

January 28th (Friday), 11:00am
Harold Frank Hall (HFH), Rm 4164

The talk will present an image-oriented modality to functionally describe artificially and biologically nanostructured surfaces, which can be used for the characterization of the atom neighborhoods on the surface of proteins. The property the hydrophobicity distribution on protein surface, but the distributions of charges and mutual electrical potentials are also considered. The actual discrete hydrophobicity distribution attached to the atoms that form a surface atom’s vicinity is replaced by an approximately equivalent hydrophobicity density distribution, computed in a standardized hexagonal or octagonal pattern around the atom. These representation of hydrophobicities has been used to compute the resemblance of surface atom neighborhoods belonging to a protein, defined as the sum of the products of hydrophobicity densities of the corresponding patches (the pattern’s central circles or angular sectors having the same position). The similitude and the interaction of a pair of atom neighborhoods are defined as their resemblance for parallel, respectively, anti-parallel orientations of the normals on the molecular surfaces in the points where the central atoms are located.

About Paul D. Cristea, Professor:

Professor Paul Cristea graduated from the Faculty of Electronics and Telecommunications of the University "Politehnica" of Bucharest (PUB) in 1962, the Faculty of Physics of the University of Bucharest in 1969, and received a Ph.D. in Technical Physics in 1970. Since then his research and teaching activities have covered an extended area of Electrical Engineering and interdisciplinary domains including topics like Genomic Signals, Digital Signal and Image Processing, Neural and Evolutionary Systems, Evolutionary Intelligent Agents, Intelligent e-Learning Environments, etc. He is the author or co-author of more then 130 published papers, 11 patents, and has contributed to more then 20 books in these fields. Currently, he is the Director of the Bio-Medical Engineering Center of PUB, Director of the Romanian Bioinformatics Society, and a correspondent member of the Romanian Academy of Sciences.

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